A Crack in Creation by Jennifer Doudna

Reviewed by K. Yanna, June 2019

A glimpse into the world of bioengineering, A Crack in Creation is a small and simple guide to CRISPR. Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR is a tool scientists use to investigate gene expression (how DNA codes for proteins). Those proteins, in turn, make up the organism. First discovered in archaea (and later bacteria), CRISPR is part of the organism’s immune system. By matching up a short sequence of DNA the organism has to the foreign DNA, CRISPR is able to determine if the foreign DNA is its own or an intruder. With vital tools, CRISPR is able to shut down entire genes, track nucleotides (components of DNA), and edit genes. A Crack in Creation goes into detail about how CRISPR works, and the effects of using CRISPR on humans.


If you are interested not only in science, but have an interest in biology, engineering, and gene editing, then A Crack in Creation is a must read.